Role of IL-12 and IFN- in Pseudomonas aeruginosa Corneal Infection
نویسندگان
چکیده
PURPOSE. In Pseudomonas aeruginosa ocular infection, T-helper cell 1–responsive mouse strains are susceptible (the cornea perforates), and neutralization of IFNbefore infection has been shown to delay the onset of perforation. IFNis the predominant cytokine induced by IL-12, and positive regulation of IL-12 by IFN, if unchecked, leads to excessive cytokine production and toxicity. Despite its potential importance, the role of IL-12 in ocular infection with P. aeruginosa remains unexplored and was the purpose of this study.
منابع مشابه
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تاریخ انتشار 2001